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Merck: encouraging results in prostate cancer

(CercleFinance.com) - AstraZeneca and Merck today announced positive results from the Phase 3 PROpel trial.


LYNPARZA (olaparib) in combination with Abiraterone significantly delayed disease progression in patients regardless of biomarker status in PROpel Phase-3 trial in first-line metastatic Castration-Resistant Prostate Cancer (mCRPC).

At a planned interim analysis, the Independent Data Monitoring Committee concluded that the trial met the primary endpoint of rPFS in men with mCRPC who had not received treatment in the first-line setting, including new hormonal agents (NHAs) or chemotherapy.

The trial also showed a trend at this interim analysis towards improved overall survival (OS).

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